I assume the toughest enemy in this gamemode would be 'plier. You can't keep the generator doors perpetually closed, or else he'll cut the power. You'll probably have to verify the generator room every five seconds. The vents will also have to be closed very often. Chud and Cob alone will probably rape your entire power supply, since you can't have the lights on in order to check for 'plier and safely close the doors, and the vents have to be closed while they're in your room, wasting your time…